Kappa And Lambda Free Light Chains Serum

If a patient has kappa myeloma their doctor will watch for a rise in the kappa numbers.

Kappa and lambda free light chains serum. The normal range for free lambda chains in serum was found to be 0 4 4 2 mg l and for free kappa. Our results suggest that an abnormal kappa lambda ratio in most cases higher than normal is a common and most likely nonspecific finding in patients with proteinuria or ckd of an unknown origin or both. Test code lab3114 kappa and lambda free light chains test name alias kappalambda 4191 collection instructions specimen collection. Polymeric forms of both types of free light chain can also occur.

Assay conditions were selected to enable measurement of free light chains in the concentration range between 0 1 and 20 mg l. Serum free light chain assay in monoclonal gammopathies. A free light chains test measures the amount of lambda and kappa free light chains in the blood. Lab tests measure free light chains in the blood and a kappa lambda ratio to help diagnose.

The kappa lambda ratio did not correlate with age proteinuria or egfr. Kappa free light chains are normally monomeric while lambda free light chains tend to be dimeric joined by disulphide bonds. Serum free light chains sflc kappa and lambda are proteins produce by immune cells that are not part of whole intact antibodies. If the amount of free light chains is higher or lower than normal it can mean you have a disorder of the plasma cells.

There are two types of light chains. Gold top serum separator sst gel preferred volume to collect. Once an abnormal free light chain flc k l ratio has been demonstrated and a diagnosis has been. The specificity of this assay for detection of monoclonal light chains relies on the ratio of free kappa and lambda k l light chains.

Marked disparity in the concentrations of involved and un involved serum free light chains in kappa vs. Likewise if a patient has lambda myeloma the lambda number will be watched.