Kappa And Lambda Free Light Chains Test

This test free light chains or serum free light chain assay or freelite is performed on a patient to look out for the signs of antibodies called immunoglobins in his her blood.

Kappa and lambda free light chains test. λ lambda free light chain. Gold top serum separator sst gel preferred volume to collect. Free light chain flc results should be considered under the following categories and investigated appropriately κ kappa free light chain. Kappa lambda light chains free with ratio urine 2 04 10 37 alternative name s immunoglobulin free light chains loinc codes performing laboratory service area must be determined methodology nephelometric 1 35.

Free light chains exist freely in the bloodstream until they deposit in the organs as amyloid fibrils which then cause organ damage. Increased lambda free light chains and a decreased kappa lambda ratio may be seen with plasma cell disorders that produce excess monoclonal lambda light chains. The test measures the levels of specific types of free light chains known as kappa and lambda and also the ratio between the two. Immunoglobulins are antibodies made by white.

There are two different types of light chain. Test code lab3114 kappa and lambda free light chains test name alias kappalambda 4191 collection instructions specimen collection. Normal test results for free light chains are. Likewise if a patient has lambda myeloma the lambda number will be watched.

In the context of mgus or myeloma significantly increased free light chain production and a markedly abnormal kappa lambda ratio indicate an increased risk of disease progression. There are two types of light chains. Serum κ λ and κ λ are all within the normal ranges. 3 3 to 19 4 mg l kappa free light chains.

With a group of conditions called plasma cell disorders dyscrasias or monoclonal gammopathies a plasma cell becomes malignant dividing uncontrollably and producing a large number of copies clones of itself that crowd out other cells in the bone. Serum κ λ and κ λ are all within the normal ranges. If the amount of free light chains is higher or lower than normal it can mean you have a disorder of the plasma cells. Normally there is a slight excess of free light chains produced so low levels of free kappa and lambda chains can be detected in the blood.